Drug-free In Vitro Activation (IVA) of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve

ConclusionsThe present drug-free IVA approach may be suitable for POR patients with DOR, as it increased the number of antral follicles. The procedure also eliminated the need for 2-day incubation with drugs and required only one surgery. This approach could allow the retrieval of more oocytes in middle-age women to achieve higher pregnancy rates and deserves proper evaluation in future randomized controlled trials.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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CONCLUSIONS: Currently we are uncertain of an effect of the routine use of NSAIDs as co-treatments in infertile women undergoing assisted reproduction in order to improve ongoing pregnancy and miscarriage rates. This is based on available data from RCTs, where very low quality evidence showed that there is no single outcome measure demonstrating a benefit with their use. Further large, well-designed randomised placebo-controlled trials reporting on live births are required to clarify the exact role of NSAIDs. PMID: 31628860 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionsDYD confers teratogenic effects after exposure to the recommended doses in pregnant women. The risks of hypospadias and cryptorchidism have biological plausibility by the known effects on male genitalia, as is the risk for spina bifida, by the proven decrease in folic acid levels. Some of these adverse fetal effects appear to be further augmented by concomitant use of IVF and ART.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
Conclusion and dissemination: We will assess the efficacy and safety of physical exercise on semen quality and reproductive outcomes in infertile men. The findings will be published in a peer-reviewed journal to provide evidence-based medical evidence for clinical decision making and the patient's lifestyle guidance. Registration information: PROSPERO CRD42019140294
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
ConclusionPregnancy in the RTO-EM group was comparable to the salpingectomy group in patients with hydrosalpinx prior to ET treatment. Radiologically guided tubal occlusion with embolization microcoils may be an alternative to salpingectomy for patients with hydrosalpinx planning IVF-ET.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract Females with symptomatic leiomyomas (fibroids) wishing to maintain fertility are faced with difficult treatment choices. These include uterine fibroid embolization (UFE), myomectomy, hormonal therapy, MRI high intensity focused ultrasound, and myolysis. This review focuses on UFE, one of the most commonly accepted minimally invasive procedural choices among patients with symptomatic fibroids wishing to retain the option of becoming pregnant in the future, and makes comparisons to myomectomy which has historically been the surgical choice for fertility-preserving fibroid treatment. Pubmed and Google Schola...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Publication date: Available online 21 September 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Luis Alonso Pacheco, Antonio Simone Laganà, Simone Garzon, Arantxa Perez Garrido, Alberto Flores Gornes, Fabio GhezziABSTRACTObjectiveTo evaluate the effectiveness of hysteroscopic outpatient metroplasty in women with T-shaped uterus and primary reproductive failure.Study DesignProspective cohort study including nulliparous women with primary unexplained infertility, repeated in vitro fertilization (IVF) failure or recurrent spontaneous miscarriage and T-shaped uterus anomaly ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
ConclusionIn women with endometrial polyps, the prevalence of CE in infertile women is higher than that in fertile women. Pregnancy outcome in infertile women with treated CE was similar to those who were infertile and without CE.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
CONCLUSIONS: This review evaluated different temperatures for embryo culture during IVF. There is a lack of evidence for the majority of outcomes in this review. Based on very low-quality evidence, we are uncertain if incubating at a lower temperature than 37°C improves pregnancy outcomes. More RCTs are needed for comparing different temperatures of embryo culture which require reporting of clinical outcomes as live birth, miscarriage, clinical pregnancy and adverse events. PMID: 31529804 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionArtificial oocyte activation with ionomycin does not adversely affect pregnancy and neonatal outcomes in patients undergoing frozen –thawed embryo transfer, which is beneficial to clinicians counseling patients on the risks of artificial oocyte activation.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
A very effective medical therapies for various types of pelvic pain is the use of dextroamphetamine sulfate. The probable mechanism for pain relief seems to be by releasing more dopamine from sympathetic nerve fibers which diminishes cellular permeability. Increased cellular permeability may be the cause of pelvic pain related to increased absorption or irritating chemicals into pelvic tissues leading to excessive inflammation. Increased inflammatory cells, especially natural killer cells, could be a cause of infertility or miscarriage.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
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