Impact of obesity on the incidence of bortezomib-induced peripheral neuropathy in patients with newly diagnosed multiple myeloma

Publication date: Available online 18 September 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Donald C. Moore, J. Tanner Ringley, David Nix, Ala’a Muslimani
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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This study aimed to determine the effect of the consumption of peel flour or pulp flour from two varieties of Solanum tuberosum (Yungay potato and Canchán potato) on the accumulation of adipose tissue, organ weight, and oxidative stress in the liver of rats. We carried out an experimental study in 24 obese Holtzman rats, divided into four groups and subjected to diets containing 10% flour from both varieties of potato. The groups were T1: Yungay peel; T2: Yungay pulp; T3: Canchán peel; and T4: Canchán pulp. When the study was completed, all the animals were slaughtered to record the weights of organs a...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Authors: Lancellotti P, De Pauw M, Claeys M Abstract Cardiovascular disease (CVD) and cancer represent the two main causes of death in industrialised countries. Both share common risk factors (diabetes, obesity, hypertension, diet, smoking, etc.). The associated timing of CVD and cancer onset is thus largely influenced by modifiable risk factors. Advances in cancer treatment have extended the lives of patients with cancer, but for some at the cost of adverse cardiovascular events. The rapidly growing number of patients surviving cancer, often in the setting of advanced age, new or pre-existing CV disease and risk f...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
In conclusion, AZA could produce a hematologic response in ~53% of patients with MDS. Furthermore, IPSS-R may reflect MDS prognosis. Further studies are required to establish the criteria for identifying patients likely to obtain maximum benefit from AZA treatment. PMID: 31966063 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, endogenous ghrelin system could be considered as a new target or treatment for metabolism disorders, cardiac diseases, neurodegenerative diseases, and tissue injuries.
Source: Peptides - Category: Biochemistry Source Type: research
In conclusion, our diagnostic prediction model uses easily obtainable information to identify children at increased risk of high blood pressure, offering an opportunity for targeted screening. This model enables to detect a higher proportion of children with high blood pressure than a strategy based on child overweight only.
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 22 January 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maxime Boidin, Anil Nigam, Valérie Guilbeault, Elise Latour, Antoine Langeard, Martin Juneau, Mathieu Gayda
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Physical activity is established as being instrumental in improving physical as well as mental health of not only healthy children but also children with chronic diseases. When good physical activity habits are established in childhood they become habitual and help the development of long-term cardiovascular health in adults. All children should be physically active in order to reduce or perhaps even help prevent childhood obesity. The current recommendations of the WHO call for at least 60 minutes of moderate to vigorous intensity physical activity daily.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
ConclusionsA higher intake of hydroxycinnamic acids, especially from chlorogenic acids—present in coffee, fruits, and vegetables—was associated with a lower incidence of breast cancer among postmenopausal women. Future observational studies are needed to corroborate these results.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Publication date: Available online 22 January 2020Source: The Lancet NeurologyAuthor(s): Jeremy Chataway, Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados Carrasco, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Gavin Giovannoni, Claudia Angela Gandini Wheeler-Kingshott, Clive Hawkins, Basil SharrackSummaryBackgroundNeurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical re...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 23 January 2020Source: Best Practice &Research Clinical HaematologyAuthor(s): Sydney Lu, Assistant Attending, Myeloma ServiceAbstractOver the course of the past decade-plus, the therapy of newly diagnosed multiple myeloma has seen incredible advances in the domains of diagnostic evaluation, active medical therapy, and response evaluation. This manuscript reviews the evaluation and management of newly diagnosed active multiple myeloma, with a focus on major clinical trials and IMWG recommendations. The paper describes a current approach for the initial evaluation and workup of a patien...
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research
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