MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654

Conclusion: MiR-654 negatively correlated with MIF and disease activity in patients with SLE. MiR-654 inhibits MIF expression via binding to MIF 3'UTR, selectively suppresses the phosphorylation of ERK and AKT, and reduces downstream inflammatory cytokine production. In vivo miR-654 treatment decreases MIF and downstream cytokine production and ameliorates murine lupus nephritis.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research