Vitamin D and Calcium Supplementation Accelerates Randall's Plaque Formation in a Murine Model

Most kidney stones are made of calcium oxalate crystals. Randall's plaque, an apatite deposit at the tip of the renal papilla, is considered to at the origin of these stones. Hypercalciuria may promote Randall's plaque formation and growth. We analyzed whether long-term exposure of Abcc6 −/− mice (a murine model of Randall's plaque) to vitamin D supplementation, with or without a calcium-rich diet, would accelerate the formation of Randall's plaque. Eight groups of mice (including Abcc6−/− and wild type) received vitamin D alone (100,000 UI/kg every 2 weeks), a calcium-enric hed diet alone (calcium gluconate 2 g/L in drinking water), both vitamin D supplementation and a calcium-rich diet, or a standard diet (controls) for 6 months.

Source: American Journal of Pathology - August 22, 2019 Category: Pathology Authors: Elise Bouderlique, Ellie Tang, Jo ëlle Perez, Amélie Coudert, Dominique Bazin, Marie-Christine Verpont, Christophe Duranton, Isabelle Rubera, Jean-Philippe Haymann, Georges Leftheriotis, Ludovic Martin, Michel Daudon, Emmanuel Letavernier Tags: Regular article Source Type: research