Subgenomic flavivirus RNA binds the mosquito DEAD/H-box helicase ME31B and determines Zika virus transmission by Aedes aegypti [Microbiology]

Zika virus (ZIKV) is an arthropod-borne flavivirus predominantly transmitted by Aedes aegypti mosquitoes and poses a global human health threat. All flaviviruses, including those that exclusively replicate in mosquitoes, produce a highly abundant, noncoding subgenomic flavivirus RNA (sfRNA) in infected cells, which implies an important function of sfRNA during mosquito...

Source: Proceedings of the National Academy of Sciences - September 16, 2019 Category: Science Authors: Giel P. Goertz, Joyce W. M. van Bree, Anwar Hiralal, Bas M. Fernhout, Carmen Steffens, Sȷef Boeren, Tessa M. Visser, Chantal B. F. Vogels, Sandra R. Abbo, Jelke J. Fros, Constantianus J. M. Koenraadt, Monique M. van Oers, Gorben P. Piȷlman Tags: PNAS Plus Source Type: research