miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2
ConclusionmiR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2.
STOMACH cancer outcomes greatly depend on one ’s general health and how far the cancer has spread. It is therefore imperative to spot any changes that may signal the condition early on. Certain eating habits may signal the deadly disease.
ConclusionOur study demonstrated a significant correlation between Nectin-4 expression and tumor grade as well as stages (p
ConclusionMSI has the potential to become a key predictor for evaluating the degree of malignancy, efficacy and prognosis of tumours. Clinically, MSI patterns will provide more valuable information for clinicians to create optimal individualized treatment strategies based on frameshift peptides vaccines.
ConclusionsIntraperitoneal injection of DFP ‐10825 demonstrated effective antitumor activity without systemic severe adverse effects via the selective delivery of RNAi molecules into disseminated tumors in the peritoneal cavity. Our current study indicates that DFP‐10825 could become an alternative option to improve the outcomes of patien ts with peritoneally disseminated gastric cancer.
AbstractThe standard treatment for locally advanced gastric cancer differs across the world. In western countries, perioperative chemotherapy or postoperative adjuvant chemoradiotherapy are the preferred treatment options, whereas in Asia, D2 gastrectomy followed by postoperative adjuvant chemotherapy is standard. In Japan, adjuvant chemotherapy with S-1 is the standard treatment for pStage II gastric cancer, whereas adjuvant chemotherapy with a doublet regimen is preferred for pStage III gastric cancer. The efficacy of preoperative neoadjuvant chemotherapy using S-1 plus cisplatin, has been investigated in selected patien...
AbstractStaged esophagectomy was developed in the mid-twentieth century in an attempt to reduce high rates of postoperative morbidity and mortality. Nowadays, the operation has almost been abandoned due to its significant disadvantages, especially the need for multiple surgeries, inability of patients to feed between operations, and morbidity of esophageal stoma. However, staged esophagectomy is still occasionally useful for very high-risk patients and in particular cases, for example multiple cancers of the aerodigestive tract and emergent esophagectomy. Staged esophagectomy is based on the division of surgical stress int...
Nanomedicine, Ahead of Print.
British Journal of Cancer, Published online: 14 October 2019; doi:10.1038/s41416-019-0600-9In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells
Publication date: 15 November 2019Source: Life Sciences, Volume 237Author(s): Heresh Moridi, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Amir Nader Emami RazaviAbstractAimsLong non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC.Main methodsPURPL and NONHSAT062994 LncRNAs and p53 gene expression levels were analyzed both in 50 pairs of cancerous and adjacent noncancerous tissue samples in GC patients using qR...
STOMACH cancer outcomes will greatly depend on the how far the cancer the has spread. It is therefore imperative to know the warning signs and get them checked out as soon as possible.