A case of desmoplastic fibroma of bone with CTNNB1 point mutation

We examined the CTNNB1 and APC sequence and found an A-to-G transition at codon 41 of CTNNB1, i.e., Thr was substituted by Ala. Our findings suggest that the dysregulation of Wnt/β-catenin signaling pathway is related to the tumorigenesis of some cases of DFB. This hypothesis indicates that there are some cases of DFB in which nuclear positive expression of β-catenin are useful for diagnosis.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research