Integrative analysis of the contribution of mRNAs and long non ‑coding RNAs to the pathogenesis of asthma.

Integrative analysis of the contribution of mRNAs and long non‑coding RNAs to the pathogenesis of asthma. Mol Med Rep. 2019 Jul 19;: Authors: Liu X, Zhang Y, Jiang H, Jiang N, Gao J Abstract Asthma, a common but poorly controlled disease, is one of the most serious health problems worldwide; however, the mechanisms underlying the development of asthma remain unknown. Long non‑coding RNAs (lncRNAs) and mRNAs serve important roles in the initiation and progression of various diseases. The present study aimed to investigate the role of differentially expressed lncRNAs and mRNAs associated with asthma. Differentially expressed lncRNAs and mRNAs were screened between the expression data of 62 patients with asthma and 43 healthy controls. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to investigate the biological functions and pathways associated with the lncRNAs and mRNAs identified. Protein‑protein interaction (PPI) networks were subsequently generated. In addition, lncRNA‑mRNA weighted co‑expression networks were obtained. In total, 159 differentially expressed lncRNAs and 1,261 mRNAs were identified. GO and KEGG analyses revealed that differentially expressed mRNAs regulated asthma by participating in the 'vascular endothelial (VEGF) signaling pathway', 'oxidative phosphorylation', 'Fc ε RI signaling pathway', 'amino sugar and nucleotide sugar metabolism', 'histidine metabolism...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research