Cell-surface markers identify tissue resident multipotential stem/stromal cell subsets in synovial intimal and sub-intimal compartments with distinct chondrogenic properties

Synovium contains multipotent progenitor/stromal cells (MPCs) with potential to participate in cartilage repair. Understanding the identity of these MPCs will allow their therapeutic potential to be fully exploited. Hence this study aimed to identify primary synovial MPCs and characterize them in the context of cartilage regeneration.

Source: Osteoarthritis and Cartilage - September 15, 2019 Category: Rheumatology Authors: Kavitha Sivasubramaniyan, Wendy J.L.M. Koevoet, Arnavaz A. Hakimiyan, Maria Sande, Eric Farrell, Martin J. Hoogduijn, Jan A.N. Verhaar, Susan Chubinskaya, Hans-J örg Bühring, Gerjo J.V.M. van Osch Source Type: research