RBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: Comparison of local effect models I and IV

Carbon ion radiotherapy of tumors of the skull base has gained increasing interest throughout the last two decades. Similar to protons, carbon ions allow for highly conformal irradiation of the tumor while sparing the surrounding normal tissue structures like brain stem, optic nerves and the chiasma due to their “inverted” depth dose profile, the so-called Bragg-peak [1]. An additional rationale for selecting carbon ions results from their higher relative biological effectiveness (RBE) relative to photons and protons, which increases with penetration depth and reaches its maximum at the distal edge of t he Bragg-peak [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research