Negative impact of polycystic ovary syndrome on bone health: a systematic review and meta-analysis

This study aimed to investigate the impact of PCOS on bone markers, BMD and fracture risk.SEARCH METHODSA systematic review and a meta-analysis were carried out. PubMed, EMBASE and Cochrane databases were searched for eligible studies from 1st of January of 1990 to 9th of October of 2018. Eligible studies enrolled women older than 18  years with PCOS, which should be diagnosed according to the Rotterdam Consensus, the Androgen Excess Society, the National Institutes of Health Consensus or the International Classification of Diseases. The studies were grouped according to patient mean BMI:<27  kg/m2 or ≥27 kg/m2. The results were polled as mean difference (MD), standardized MD (SMD) and hazard ratio (HR).OUTCOMESOverall, 921 studies were retrieved, and 31 duplicated studies were removed. After screening the titles and abstracts, 80 studies were eligible for full text reading. Of those, 23 studies remained for qualitative synthesis. With the exception of one study, all studies were considered high quality based on the Newcastle –Ottawa scale (NOS; score ≥6). Meta-analysis was performed in 21 studies, with a total of 31 383 women with PCOS and 102 797 controls. Women with PCOS with BMI<27  kg/m2 had lower BMD of the total femur (MD, −0.04; 95% CI, −0.07 to 0.00; I2 = 31%;P = 0.22) and spine (MD, −0.07; 95% CI, −0.13 to −0.01; I2 = 70%;P <  0.01) when compared with the control group, whereas for women with BMI ≥27 kg/m2 no differenc...
Source: Human Reproduction Update - Category: OBGYN Source Type: research