CC bond formation using ThDP-dependent lyases.

CC bond formation using ThDP-dependent lyases. Curr Opin Chem Biol. 2013 Apr;17(2):261-70 Authors: Müller M, Sprenger GA, Pohl M Abstract The present review summarizes recent achievements in enzymatic thiamine catalysis during the past three years. With well-established enzymes such as BAL, PDC and TK new reactions have been identified and respective variants were prepared, which enable access to stereoisomeric products. Further we highlight recent progress with 'new' ThDP-dependent enzymes like MenD and PigD, which catalyze the Stetter-like 1,4 addition of aldehydes and YerE, which is the first known ThDP-dependent enzyme accepting ketones as acceptors. PMID: 23523314 [PubMed - in process]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research