Radiation dosimetry considerations for skeletal survey imaging of multiple myeloma

Multiple myeloma is a haematological disease in which clonal expansion of neoplastic plasma cells in the bone marrow causes production of monoclonal immunoglobulin [1,2]. The neoplastic plasma cells interact with the bone and bone marrow microenvironment commonly resulting in both local and generalised bone resorption leading to osteopenia and the formation of osteolytic ( ‘lytic’) lesions, visible under radiological and nuclear medicine examination as focal regions of low bone density. The presence of myeloma related bone disease is the most frequent cause of the debilitating symptoms, pain and pathological fractures, in addition to anaemia, hypercalcaemia and re nal failure [3,4].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research