Ondansetron effects on apamin-sensitive small conductance calcium-activated potassium currents in pacing induced failing rabbit hearts

Ondansetron, a widely prescribed antiemetic, has been implicated in drug-induced long QT syndrome. Recent patch clamp experiments have shown that ondansetron inhibits the apamin sensitive calcium activated potassium current (IKAS).

Source: Heart Rhythm - September 8, 2019 Category: Cardiology Authors: Dechun Yin, Na Yang, Zhipeng Tian, Adonis Z. Wu, Dongzhu Xu, Mu Chen, Nicholas J. Kamp, Zhuo Wang, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, Michael Rubart-von der Lohe, Peng-Sheng Chen, Thomas H. Everett Source Type: research