Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1.

In conclusion, this study demonstrated that MeHg inhibited the TCDD-mediated induction of CYP1A1 through a posttranslational mechanism and confirms the role of HO-1 in a MeHg-mediated effect. PMID: 23541843 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23541843?dopt=Abstract

Source: Toxicology Letters - May 22, 2013 Category: Toxicology Authors: Amara IE, Anwar-Mohamed A, El-Kadi AO Tags: Toxicol Lett Source Type: research

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