Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro.

In conclusion, the results of this study suggested that OTA-induced oxidative DNA damage triggered the ATM-dependent pathways, which ultimately elicited a G2 arrest in GES-1 cells. PMID: 23515941 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23515941?dopt=Abstract

Source: Archives of Toxicology - March 21, 2013 Category: Toxicology Authors: Cui J, Liu J, Wu S, Wang Y, Shen H, Xing L, Wang J, Yan X, Zhang X Tags: Arch Toxicol Source Type: research