Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

Applied Physiology, Nutrition, and Metabolism, e-First Articles. Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, whi le no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.

Source: Applied Physiology, Nutrition, and Metabolism - April 17, 2019 Category: Physiology Authors: Jay R. Hoffman John A. Rathmacher Jennifer Robinson Yftach Gepner Hagit Cohen Source Type: research