Chemodiversity and Antiproliferative Activity of the Essential Oil of Schinus molle L.Growing in Jordan.

Chemodiversity and Antiproliferative Activity of the Essential Oil of Schinus molle L.Growing in Jordan. Chem Biodivers. 2019 Sep 01;: Authors: Afifi F, Aboalhaija NH, Awwad O, Khalil E, Abbassi R, Abaza IF Abstract The leaves and unripe and fully-grown fruits of Schinus molle were collected from three geographical regions of Jordan:Amman (the Mediterranean), Madaba (Irano-Turanean), and Sahab (Saharo-Arabian).The hydro-distilled volatile oils of fresh and driedleaves and fruits were analyzed by gas chromatography-mass spectrometry (GC/MS).The actual composition of the emitted volatiles was determined using Solid Phase Micro-Extraction (SPME). Alphaand β- phellandrenes were the majorcomponents in all the analyzed samples. Quantitative differences were observed in the obtained essential oils (0.62 - 5.25%).Additionally, cluster analysis was performed. Biologically,the antiproliferative activity of the essential oil, ethanol, and water extracts of the fruits and leaves was screened onCaco2, HCT116, MCF7, and T47Dcell lines. The essential oil and ethanol extracts exhibited a dose-dependent inhibition of cell growth with IC 50 ' s ranging between 21- 65μg/mL.The water extract did not exhibitany antiproliferative activity against the investigated cell lines. PMID: 31475446 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research