322 Upregulation of SERPINB3/B4 and S100A7-9 in hidradenitis suppurativa/acne inversa

In this study we investigated the expression and localization of the transglutaminase inhibitory proteins (SERPINB3/B4) and the antimicrobial proteins (S100A7-A9) in HS. Comparative analysis of gene expressi on in the lesional vs healthy appearing skin from microarray data of 8 affected patients and 4 healthy individuals showed 705 statistically significant upregulated genes and 482 downregulated (fold change>2, p
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research