MiR-421 inhibition protects H9c2 cells against hypoxia/reoxygenation-induced oxidative stress and apoptosis by targeting Sirt3.

CONCLUSION: The miR-421-Sirt3-Jun N-terminal kinase/activator protein 1 axis is a novel molecular mechanism that accommodates hypoxia/reoxygenation-induced oxidative stress and apoptosis and provides a new direction for the study and treatment of hypoxia/reoxygenation. PMID: 31469043 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31469043?dopt=Abstract

Source: Perfusion - August 29, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Liu Y, Qian XM, He QC, Weng JK Tags: Perfusion Source Type: research

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