Factors Associated with Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study in Private Health Facilities in Tema Metropolis, Ghana.

Factors Associated with Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy: A Cross-Sectional Study in Private Health Facilities in Tema Metropolis, Ghana. J Trop Med. 2019;2019:9278432 Authors: Amankwah S, Anto F Abstract Introduction: Intermittent preventive treatment of malaria in pregnancy with sulfadoxine pyrimethamine (IPTp-SP) is effective in preventing the adverse consequences of malaria on birth outcomes. Methods: A cross-sectional survey was carried out among antenatal and postnatal women and midwives at private health facilities in Tema using the mixed method to investigate factors associated with uptake of IPTp-SP. Antenatal and postnatal women were consecutively enrolled and data on their sociodemographic characteristics and antenatal service utilization collected using a questionnaire and review of antenatal care (ANC) records. In-depth interviews involving attending midwives were conducted and data on ANC service delivery collected. The interviews were manually analyzed. Bivariate and multiple logistic regression analyses were done to determine factors associated with uptake of SP. Results: Of the 382 respondents, 178 (46.6%) took ≥ 3 doses of SP. Uptake was similar for those who had delivered and those yet to deliver (χ 2 =2.94, p> 0.05). Ninety-seven of the 176 (55.1%) women who initiated antenatal visit during the first trimester received ≥ 3 doses of SP whilst 42.0% (76/181) of those who started dur...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research

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[Vanguard] Amidst the COVID-19 pandemic in sub-Saharan Africa, malaria - one of the world's oldest diseases - is impacting disproportionately on pregnant women and children aged under five.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Conclusion Inadequate knowledge and irrational antimalarials dispensing practices were reported among the community pharmacists in Khartoum State. Although training was a significant predictor of pharmacists ’ knowledge regarding malaria and its treatment, health authorities were not providing regular training for the practicing pharmacists.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Abstract Dihydroartemisinin-piperaquine (DHA-PQ) provides highly effective therapy and chemoprevention for malaria in pregnant African women. PQ concentrations>10.3 ng/mL have been associated with reduced maternal parasitemia, placental malaria and improved birth outcomes. We characterized the population pharmacokinetics (PK) of PQ in a post-hoc analysis of human immunodeficiency virus (HIV)-infected and -uninfected pregnant women receiving DHA-PQ as chemoprevention every 4 or 8 weeks. The effects of covariates such as pregnancy, nutritional status (body mass index, BMI) and efavirenz (EFV)-based antiretroviral...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract Intermittent preventive treatment in pregnancy (IPTp) with monthly sulfadoxine-pyrimethamine (SP) is recommended for malaria-endemic parts of Africa, but efficacy is compromised by resistance and, in recent trials, dihydroartemisinin-piperaquine (DP) has shown better antimalarial protective efficacy. We utilized blood samples from a recent trial to evaluate selection by IPTp with DP or SP of Plasmodium falciparum genetic polymorphisms that alter susceptibility to these drugs. The prevalence of known genetic polymorphisms associated with altered drug susceptibility was determined in parasitemic samples, in...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
AbstractPurpose of ReviewSequestration ofPlasmodium-infected cells in the placenta causes significant adverse effects on mothers and their fetuses. With progress in understanding placental malaria and associated adverse consequences, this review addresses the situation in an area with high prevalence, in Blue Nile State, Sudan, where protective interventions are not adequately provided.Recent FindingsSeveral studies have confirmed that malaria infection during pregnancy with parasites in the placenta, even at sub-patent level detected by molecular techniques, can result in maternal morbidity, fetal growth restriction, and ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
This study sought to investigate the prevalence of molecular markers associated with resistance to sulfadoxine-pyrimethamine (SP) and artemether-lumefantrine (AL) in Southern and Western provinces in Zambia. SP is used primarily for intermittent preventive treatment during pregnancy, while AL is the first-line antimalarial for uncomplicated malaria in Zambia. Blood samples were collected from household members of all ages in a cross-sectional survey conducted during peak malaria transmission, April to May of 2017, and amplified by polymerase chain reaction (PCR). Amplicons were then analysed by high-resolution melt followi...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Since the genesis of living organisms, the selection pressure or survival competition of any species has emerged through continuous, uncountable mutations. Prior to the emergence of Homo sapiens from subhuman primates, many pathogens, such as malaria species, have long and severely affected them(1). Beginning 100,000 to 40,000 years ago, modern humans migrated from Africa and adapted their cultures and phenotypes to extremes of altitudes, temperature, and humidity throughout the planet.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Brief biography Source Type: research
Malaria in pregnancy (MiP) is an important public health problem across sub-Saharan Africa. The package of measures for its control in Ghana in the last 20 years include regular use of long-lasting insecticide...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
While evidence has shown an association between place of birth and birth outcomes, factors contributing to the choice of home birth have not been adequately investigated in Tanzania while more than 30% of deli...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
AbstractPurpose of ReviewPlacental malaria is the primary mechanism through which malaria in pregnancy causes adverse perinatal outcomes. This review summarizes recent work on the significance, pathogenesis, diagnosis, and prevention of placental malaria.Recent FindingsPlacental malaria, characterized by the accumulation ofPlasmodium-infected red blood cells in the placental intervillous space, leads to adverse perinatal outcomes such as stillbirth, low birth weight, preterm birth, and small-for-gestational-age neonates. Placental inflammatory responses may be primary drivers of these complications. Associated factors cont...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
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