Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis.

CONCLUSIONS: CF neutrophil immunometabolism is altered in response to inflammation. NLRP3 inflammasome inhibition may have an anti-inflammatory and anti-infective role in CF.
PMID: 31454256 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - August 26, 2019 Category: Respiratory Medicine Authors: McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O'Neill LA, Reeves EP, McElvaney NG Tags: Am J Respir Crit Care Med Source Type: research