Case of the Week 558

This week's case presents a bit of a conundrum. The patient is a 50 year old woman with recent travel to Kenya. She presents with acute onset of fever and chills and was tested by a rapid malaria antigen test (P. falciparumand Pan-malaria antigens) and was negative. A follow-up Giemsa-stained thin blood smear from the same blood collection shows the following:Identification based on the blood smear? How might this correlate with the rapid antigen test?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs

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Conclusion: Metabolite extract of S. hygroscopicus subsp. hygroscopicus causes morphological damage, decreases the degree of parasite-infected erythrocytes and the DNA density of P. falciparum 3D7 in vitro. PMID: 31673263 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
AbstractMalaria is caused byPlasmodium parasite. It is transmitted by femaleAnopheles bite. Thick and thin blood smears of the patient are manually examined by an expert pathologist with the help of a microscope to diagnose the disease. Such expert pathologists may not be available in many parts of the world due to poor health facilities. Moreover, manual inspection requires full concentration of the pathologist and it is a tedious and time consuming way to detect the malaria. Therefore, development of automated systems is momentous for a quick and reliable detection of malaria. It can reduce the false negative rate and ...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Authors: Camarlinghi G, Parisio EM, Nardone M, Mancini F, Ciervo A, Boccolini D, Mattei R Abstract Both malaria and relapsing fever Borrelia are infectious diseases characterized by fever, headache, myalgia, hepatosplenomegaly and tendency to relapse. Exflagellation of microgametocyte in malarial parasites is seen only in the definitive host, i.e., mosquitoes. Here we report an unusual case of a 23-year-old man who presented Plasmodium vivax infection with multiple exflagellated microgametes in the peripheral blood smear. PMID: 31524945 [PubMed - as supplied by publisher]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Answer toParasite Case of the Week 558:Plasmodium falciparummalaria,>10% parasitemia. NEGATIVE rapid antigen.Sowhy is the rapid antigen test negative???As noted by our readers, there are many possible reasons for apositive blood smear and negative rapid malaria antigen test (RDT). Here are our options, along with the reasons why each is or isn't a likely explanation in this case:This is babesiosis, and not malaria. This is a very important consideration given the morphologic similarities betweenBabesiaspp. andPlasmodium falciparum.However, the moprhologic features in this case are highly consistent withP. falciparu...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Conclusion: AZ-PQ is a promising candidate for IPTp. PMID: 31405866 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract Malaria is a parasitic infection of global importance but has a high prevalence in the developing countries. Renal failure is a common complication of severe Plasmodium falciparum malaria and has been reported in up to 40% of all cases. Acute kidney injury (AKI), however, is not commonly associated with Plasmodium vivax infection. In those patients who develop AKI following P. vivax infection, the cause is commonly attributed to mixed undiagnosed falciparum infection or coexistent sepsis, dehydration, or hypotension. Infrequently, an association of P. vivax infection with thrombotic microangiopathy (TMA) ...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Blood smear microscopy remains the gold-standard method to diagnose and quantify malaria parasite density. In addition, parasite genotyping of select loci is the most utilized method for distinguishing recrude...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
ConclusionsMass azithromycin distributions were associated with a reduced prevalence of malaria parasitemia in this trial, suggesting one possible mechanism for the mortality benefit observed with this intervention. Trial registrationThe trial was registered on (NCT02048007).
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ute;M Abstract Avian malaria is a widespread infection caused by parasites from the Order Haemosporida. Indeed, Neotropical swifts are interesting models for host-parasite coevolution studies due to their unique life history that may allow them to escape parasitism. Considering this, we evaluated haemosporidians from Neotropical swifts. We collected blood and prepared smears from 277 individuals from waterfalls in Brazil. Despite low parasitemia or absence of parasites detected by microscopy haemosporidian infection was detected in 44 swifts (15.8%) using a screening PCR that amplifies a 154-nucleotide segment of ...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Ambient temperature is an important determinant of malaria transmission and suitability, affecting the life-cycle of the Plasmodium parasite and Anopheles vector. Early models predicted a thermal malaria transmis...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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