1028 - mitochondria metabolism in quiescent and cycling hematopoietic stem cells

Cellular metabolism is an area of recent intense research interest. However, the metabolic requirements for adaptations of stem cells to their niches remain largely unaddressed. The cell metabolism may be quite different in quiescent and cycling HSCs.Most of the hematopoietic stem cells (HSCs) within the bone marrow show quiescent state. By contrast, upon stress hematopoiesis, HSCs actively divide to regenerate hematopoietic system with the appropriate balance between self-renewal and differentiation divisions.

Source: Experimental Hematology - July 31, 2019 Category: Hematology Authors: Toshio Suda Source Type: research