Differential Activation of the Transcription Factor IRF1  Underlies the Distinct Immune Responses Elicited by Type I and III Interferons

Type I IFNs, but not type III IFNs (IFN λ), promote inflammation at the site of infection. Forero et al. find that differential expression of proinflammatory genes results from selective induction of the transcription factor IRF1 by type I IFNs. Type III IFNs induce a tissue repair program, suggesting a division of labor that spans proi nflammatory and tissue repair functions to promote protective immunity.

Source: Immunity - August 26, 2019 Category: Allergy & Immunology Authors: Adriana Forero, Snehal Ozarkar, Hongchuan Li, Chia Heng Lee, Emily A. Hemann, Marija S. Nadjsombati, Matthew R. Hendricks, Lomon So, Richard Green, Chandra N. Roy, Saumendra N. Sarkar, Jakob von Moltke, Stephen K. Anderson, Michael Gale, Ram Savan Tags: Article Source Type: research