Novel Polycationic Photosensitizers for Antibacterial Photodynamic Therapy.

Novel Polycationic Photosensitizers for Antibacterial Photodynamic Therapy. Adv Exp Med Biol. 2019 Aug 25;: Authors: Meerovich GA, Akhlyustina EV, Tiganova IG, Lukyanets EA, Makarova EA, Tolordava ER, Yuzhakova OA, Romanishkin ID, Philipova NI, Zhizhimova YS, Romanova YM, Loschenov VB, Gintsburg AL Abstract Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment.This work was dedicated to the study of photophysical and antibacterial properties of new photosensitizers (PS) based on polycationic phthalocyanines and synthetic bacteriochlorins for photodynamic inactivation of P. aeruginosa bacteria and their biofilms. Gram-negative bacteria P. aeruginosa are often found in infected wounds, presumably in biofilm state and are characterized by rather low susceptibility to APDT, which is a problem. PS were studied for possible aggregation at various concentrations by means of absorption and fluorescence spectroscopy. The results of studies of the ZnPcChol8, (3-PyHp)4BCBr4 and (3-PyEBr)4BCBr4 in water and serum confirm the assumption of a low degree of their aggregation at high concentrations.Consequently, their photodynamic efficiency is high enabling to use these PS at high concentrations to se...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research