Theranostic nanocomplex of gold-decorated upconversion nanoparticles for optical imaging and temperature-controlled photothermal therapy

Publication date: Available online 23 August 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): Gonzalo Ramírez-García, Miguel Ángel Honorato-Colin, Elder De la Rosa, Tzarara López-Luke, Sandeep S. Panikar, José de Jesús Ibarra-Sánchez, Valeria PiazzaAbstractThe multifunctional hybrid nanomaterials could bring alternative solutions to current public health problems like cancer diagnosis and treatment. In this work, the near-infrared-activated NaYF4:Yb,Er up-conversion nanoparticles (UCNPs) were synthesized and covalently decorated with sub-10 nm gold nanoparticles (AuNPs) in a 10 min reaction. The UCNPs in the UCNPs-AuNPs complex converted the deep-penetrating 975 nm near-infrared photons into visible emissions, which were simultaneously used for multiple applications: i) plasmon-induced photothermal therapy, ii) in situ sensing and control of the temperature (nano-thermometer), and iii) contrast agent for fluorescence imaging and cell tracking at the tissues transparency window. The effective energy transfer of green emissions and consequent temperature increment was enhanced by the short separation between donor (UCNPs) and acceptor nanoparticles (AuNPs). The induced hyperthermia locally triggered irreversible cancer cell damage, considerably reducing the cell viability upon 5 min of NIR irradiation but being practically inert in the absence of infrared light exposure. In...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research

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Many radiologists are concerned that mammography information provided by referring physicians is confusing for patients, and they want to be more involved in screening-related discussions, according to a  studyrecently published in theJournal of Breast Imaging. The group of researchers led by Shadi Aminololama-Shakeri, MD,Chief of Breast Imaging Section at theUniversity of California Davis in Sacramento, California found thatthere is a wide variety of breast cancer screening guidelines across professional societies, and the lack of uniformity makes understanding the purpose of mammography confusing and frustratin...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
ConclusionIn breast cancer, D and f values show significant differences according to TSR, and D value is lower in collagen dominant type than in fibroblast dominant or lymphocyte dominant types.
Source: European Journal of Radiology - Category: Radiology Source Type: research
CONCLUSION: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX. PMID: 31538904 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
Publication date: Available online 20 September 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Tasleem Kausar, MingJiang Wang, Muhammad Idrees, Yun LuAbstractAmong the predominant cancers, breast cancer is one of the main causes of cancer deaths impacting women worldwide. However, breast cancer classification is challenging due to numerous morphological and textural variations that appeared in intra-class images. Also, the direct processing of high resolution histological images is uneconomical in terms of GPU memory. In the present study, we have proposed a new approach for breast histopathological image ...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 20 September 2019Source: International Journal of Surgery Case ReportsAuthor(s): Shin Takayama, Kaishi Satomi, Masayuki Yoshida, Chikashi Watase, Takeshi Murata, Sho Shiino, Kenjiro Jimbo, Akihiko SutoABSTRACTINTRODUCTIONSpontaneous regression of a malignant tumor is defined as “the partial or complete disappearance of a malignant tumor in the absence of any treatment.” Herein, we report a case of occult breast cancer with axillary lymph node metastasis that showed spontaneous tumor regression based on the histopathological findings.PRESENTATION OF THE CASEA 67-year-old woman ...
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Kikuchi K, Miki A, Satoh H, Iba N, Sato-Sakuma R, Beppu H, Sawada Y Abstract Patient narratives of adverse drug events (ADEs) often differ from the symptoms listed on the package inserts of pharmaceutical products using common ADE terminology and could be a source of great comfort to patients with the same disease. To explore this idea, we analyzed written narratives obtained from 48 patients with breast cancer using the NPO Corporation Database of Individual Patients' Experiences, Japan (DIPEx-Japan). Our analysis aimed to determine the utility of an "Adverse Drug Event Database" for use in clin...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Abstract: Everolimus is a mammalian target of rapamycin (m-TOR) inhibitor that has been approved for the treatment of hormone receptor-positive advanced breast cancer, metastatic renal cancer, and neuroendocrine tumors. Although therapeutic drug monitoring (TDM) of everolimus is well established in the transplantation field, it is not currently performed in oncology. The last consensus conference about the TDM of everolimus states that for the use of everolimus in oncology, “further studies are required to determine the clinical utility of TDM for everolimus in oncology settings.” In this review, the authors ...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Review Article Source Type: research
Conclusions: The abnormal location of FLT3 caused by different glycosylation status leads to the distinguishing signaling pathways. Targeting on FLT3 glycosylation may provide a new perspective for therapeutic strategies. Abbreviations: ABCG2: ATP-binding cassette transporter breast cancer resistance protein; ATF: activating transcription factor; AML: acute myeloid leukemia; CHOP: CCAAT-enhancer-binding protein homologous protein; 2-DG: 2-deoxy-D-glucose; EFS: event free survival; EPO: erythropoietin; EPOR: erythropoietin receptor; ERS: endoplasmic reticulum stress; FLT3: FMS-like tyrosine kinase 3; GPI: glycosylphosphatid...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
We describe the case of a 52-year-old female outpatient who developed OIC while receiving oxycodone for pain due to cancer with multiple bone metastases. Although she did not have brain metastasis, opioid withdrawal syndrome (OWS) developed after taking naldemedine orally. Her Clinical Opiate-Withdrawal Score (COWS) was 19 (moderate symptoms). However, she recovered from OWS on intravenous fentanyl and a continuous infusion of oxycodone. She did not develop OWS thereafter and was discharged two days after recovery. PMID: 31534081 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Contributors : Na Hao ; Rong Xiang ; Yunping LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of MDA-MB-231 breast tumor cell from knocking-down phosphodiesterase 3A (PDE3A), a cyclic nucleotide phosphodiesterase. Results provide insight into the role of PDE3A in breast tumor progression and metastasis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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