Structural kinetics of the myosin power stroke [Biochemistry]

We have used transient kinetics, nanosecond time-resolved fluorescence resonance energy transfer (FRET), and kinetics simulations to resolve a structural transition in the Dictyostelium myosin II relay helix during the actin-activated power stroke. The relay helix plays a critical role in force generation in myosin, coupling biochemical changes in the ATPase...

Source: Proceedings of the National Academy of Sciences - April 30, 2013 Category: Science Authors: Muretta, J. M., Petersen, K. J., Thomas, D. D. Tags: Biological Sciences Source Type: research