Pioglitazone downregulates Twist-1 expression in the kidney and protects renal function of Zucker diabetic fatty rats

ConclusionsThis study shows that PIO can downregulate Twist-1 expression in the kidney, inhibit renal fibrosis and protect renal function in ZDF rats. These PIO-mediated effects are independent of glycemic control.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research