Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients

ConclusionsSurprisingly, the first dose already achieved exposure comparable to steady-state conditions. The approved daily dose of 400  mg was adequate in our patient population. Thus, it seems that in septic patients a loading dose on the first day of treatment with moxifloxacin is not required.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research