Research progress and prospects of tissue engineering scaffolds for spinal cord injury repair and protection.

Research progress and prospects of tissue engineering scaffolds for spinal cord injury repair and protection. Regen Med. 2019 Aug 22;: Authors: Ma Z, Lu Y, Yang Y, Wang J, Kang X Abstract Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tissue engineering has gradually replaced the single transplantation approach to become a focus of research that brings new opportunities for the clinical treatment of SCI. PMID: 31436130 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - Category: Genetics & Stem Cells Authors: Tags: Regen Med Source Type: research

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Despite the fact that one fifth of Americans live with disability, caring for these patients is not routinely part of the undergraduate medical student curriculum. An innovative session addressing care of patients with spinal cord injury was developed for medical students and led by physiatrists, faculty experts in communications, and individuals with spinal cord injury. A mixed-method design was used in evaluating students' knowledge, skills, and attitudes following this curriculum. Quantitative evaluation was performed with a written essay question and checklist items from an objective structured clinical examination sta...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Education & Administration Source Type: research
Publication date: Available online 15 October 2019Source: Stem Cell ResearchAuthor(s): Tomoyuki Kurose, Shinya Takahashi, Takashi Otsuka, Kei Nakagawa, Takeshi Imura, Taijiro Sueda, Louis YugeAbstractSpinal cord ischemia is a potential complication of thoracoabdominal aortic surgery that may induce irreversible motor disability. We investigated the therapeutic efficacy of simulated microgravity-cultured mesenchymal stem cell (MSC) injection following spinal cord ischemia−reperfusion injury. Sprague-Dawley rats were divided into sham, phosphate-buffered saline (PBS), normal gravity-cultured MSC (MSC-1G), and simulated...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Conclusion: Nurses consider discussing patient sexuality as important but are hindered due to multiple factors. Organizational efforts targeted at knowledge expansion are needed to break the taboo and remove preconceptions. Nurses should provide opportunities to discuss the subject to intercept sexuality-related problems. IMPLICATIONS FOR REHABILITATION The specific tasks of each profession within the multidisciplinary team regarding patient sexuality should be discussed, agreed upon and protocolized. Adding a sexologist in the multidisciplinary team may be of benefit as well as structurally incorporating an appointment wi...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Spinal Cord, Published online: 10 October 2019; doi:10.1038/s41393-019-0363-4Factors affecting long-term mortality rate after diagnosis of syringomyelia in disabled spinal cord injury patients: a population-based study
Source: Spinal Cord - Category: Research Authors: Source Type: research
Abstract Although no damage occurs in the brains of individuals with spinal cord injury, structural and functional reorganization occurs in the sensorimotor cortex because of the deafferentation of afferent signal input from below the injury level. This brain reorganization that is specific to individuals with spinal cord injury is speculated to contribute to the improvement of the motor function of the remaining upper limbs. However, no study has investigated in detail the motor function above the injury level. To clarify this, we designed an experiment using the handgrip force steadiness task, which is a popular...
Source: Experimental Brain Research - Category: Neuroscience Authors: Tags: Exp Brain Res Source Type: research
Conclusions: The insights obtained from end-users and clinicians provide guidelines to optimize the development of novel FES-garments, and strategies for bringing the device to the market. The themes identified can serve to inform other rehabilitation and assistive technology developers with processes and ideas on how to meet these groups' needs. IMPLICATIONS FOR REHABILITATION Participants with neurological paralysis have interest and critical views on new rehabilitation and assistive technology, and the repercussions of using new technologies to address their function, health and wellbeing. The FES-garment design present...
Source: Disability and Rehabilitation. Assistive Technology. - Category: Rehabilitation Authors: Tags: Disabil Rehabil Assist Technol Source Type: research
Powered exoskeletons are used to help people with lower limb paralysis get on their feet and allow post-stroke patients to recover faster. They’re pretty impressive devices, but people who are severely disabled, including those suffering from t...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Neurosurgery Rehab Source Type: blogs
Conclusion: The proposed indicators have a low administrative burden and will ensure feasibility of screening for depression and anxiety at important transition points for individuals with SCI/D. We anticipate that the current structures have inadequate resources for at-risk individuals identified during the screening process. PMID: 31573461 [PubMed - in process]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conclusions: The participants reported AT was a unique and versatile approach that benefits the multi-dimensional aspects of the health of individuals with SCI/D. They successfully integrated AT into their clinical practice despite the barriers faced by professionals and clients. PMID: 31573458 [PubMed - in process]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Acute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associate...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
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