3T MRI can identify visual sign to distinguish MS

European researchers have identified a visual sign on 3-tesla MR images that...Read more on AuntMinnie.comRelated Reading: 7T MRI and 3D printing uncover signs of severe MS 7T MRI shows path to MS progression Contrast not needed for follow-up MRI on MS patients MRI shows drug slows brain atrophy in MS patients MRI links iron in the brain to multiple sclerosis
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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ConclusionsThis study shows that a relapse is accompanied by an increase in MS-related fatigue. Moreover, autonomic dysfunctions and introversion, more than depression and apathy, play a major role in the explanation of MS-related fatigue. This finding represents additional evidence for the relationship between inflammation, vagal afferent signalling, autonomic dysfunctions, introversion and the feeling of MS-related fatigue.KeywordsMultiple Sclerosis, fatigue, relapse, autonomic dysfunctions, vagal afferents
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mihaela Bustuchina VlaicuAbstractThis is a review paper, essentially a commentary with summary of literature that actualizes the problem of epilepsy in patients with multiple sclerosis. There is a bidirectional relation between multiple sclerosis and epilepsy. A possible associate pathophysiological pathway is considered. In multiple sclerosis, a combination of grey matter involvement and inflammation could influence epileptogenesis. Patients with multiple sclerosis have individual profiles and an inter-individual...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Andrew B. Wolf, Lana Zhovtis Ryerson, Krupa Pandey, Brett M. McGettigan, Timothy Vollmer, John R. Corboy, Enrique AlvarezAbstractRituximab is a chimeric anti-CD20 monoclonal antibody that is an effective therapy for multiple sclerosis. Rituximab has been associated with the development of serum sickness (type III hypersensitivity) characterized by arthralgia, fever, and rash during the treatment of other conditions, such as rheumatoid arthritis. Here we describe serum sickness associated with rituximab in multiple...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Leandro Pires Araujo, Juliana Terzi Maricato, Marcia Grando Guereschi, Maisa Carla Takenaka, Vanessa M. Nascimento, Filipe Menegatti de Melo, Francisco J. Quintana, Patrícia C. Brum, Alexandre S. BassoSummaryNoradrenaline (NE), the main neurotransmitter released by sympathetic nerve terminals, is known to modulate the immune response. However, the role of the sympathetic nervous system (SNS) on the development of autoimmune diseases is still unclear. Here, we report that the SNS limits the generation of pathogenic T cells and...
Source: Cell Reports - Category: Cytology Source Type: research
In this study, we present an electrochemical method to detect SMEnzyme concentration that is more sensitive and much faster than currently available commercial assays. For detection and the amplification of the SMEnzyme signal, methylene blue (MB)-encapsulated sphingomyelin (SM)-based liposome with 50 % cholesterol was synthesized via sonication method. Then the target SMEnzyme causes the free release of the MB from the MB-liposome formulation which can be detected on GCE||Au-PAni/N,S-GQDs electrode, prepared via interfacial polymerization and then self-assembly approach. The change of SM to gel state bilayer with increasi...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
ConclusionUntil now, WEMINO syndrome secondary to trauma has not been previously documented. Our patient was effectively treated with conservative measures alone.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThe ideal treatment option for MS is becoming increasingly complex, with the need to balance benefit and risks. Our results suggest that starting with FTY affects the long-term disease outcome similarly to escalating from IFN- β1a to FTY.
Source: Journal of Neurology - Category: Neurology Source Type: research
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of these SNPs are associated with higher levels of ANKRD55 in CD4+ T cells. The biological function of ANKRD55 is unknown, but given that ankyrin repeat domains constitute one of the most common protein-protein interaction platforms in nature, it is likely to function in complex with other proteins. Thus, identification of its protein interactomes may provide clues. We identified ANKRD55 interactomes via rec...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The two will be developing and studying an app to help manage and improve psychological outcomes in people with multiple sclerosis
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
ConclusionsEmotion dysregulation is associated with symptoms of depression and anxiety in PwMS. Given the malleability of this construct, this study underscores the importance of further investigating emotion dysregulation, and possibly adopting it as a surrogate endpoint in interventions targeting affective disorders in PwMS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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