Role of miR ‑34 in gastric cancer: From bench to bedside (Review).

Role of miR‑34 in gastric cancer: From bench to bedside (Review). Oncol Rep. 2019 Aug 16;: Authors: Xiong S, Hu M, Li C, Zhou X, Chen H Abstract Gastric cancer (GC) is a prevalent digestive system malignancy that is associated with a poor prognosis specifically for advanced‑stage patients. MicroRNAs (miRNAs) are small, non‑coding RNAs that have been reported to play roles as oncogenes or tumour suppressors in all types of cancer, including GC, by post‑transcriptionally regulating cancer‑related genes. Recently, miR‑34a and miR‑34b/c, members of the microRNA‑34 (miR‑34) family, were identified to be direct transcriptional targets of the onco‑suppressor p53. In this review, we report that miR‑34 is epigenetically downregulated or silenced in GC tissues and cell lines, changes which may result from mutations in p53 or DNA methylation and histone modifications of the miR‑34 promoter regions. Moreover, miR‑34 has been identified as a tumour‑suppressor in GC. p53‑induced miR‑34 regulates several different target genes and signalling pathways, inducing apoptosis, senescence, and cell cycle arrest and repressing GC cell proliferation, migration and metastasis, thus contributing to the suppression of carcinogenesis and GC cancer progression. Furthermore, miR‑34 is a novel prognostic and predictive biomarker in GC, and restoring miR‑34 expression by delivering miR‑34 mimics may be a promising therapeutic strategy for the treatm...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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This study aimed to devise a nomogram to predict the conditional probability of cancer-specific survival (CPCS) in gastric cancer (GC) patients after D2 lymphadenectomy.MethodsClinicopathological data for 2,596 GC patients who underwent D2 lymphadenectomy in an Eastern institution (the training cohort) were retrospectively analysed. Cancer-specific survival (CSS) was predicted using Cox regression models. A nomogram was constructed to predict CPCS at 3 and 5 years post-gastrectomy. Two external validations were performed using a cohort of 2,198 Chinese patients and a cohort of 504 Italian patients.ResultsIn the training ...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionThis population-based study highlights that a significant proportion of the patients did not receive perioperative treatment. More research is necessary to elucidate the importance of the individual components of perioperative treatment.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
(WASHINGTON) — U.S. health officials said Friday they are investigating low levels of a potentially dangerous contaminant in the popular heartburn medication Zantac and related generic drugs. For now, though, the Food and Drug Administration said patients can continue taking their medications. The agency said it has detected a “probable” cancer-causing chemical in the medications, which are sold as both prescription and over-the-counter treatments to treat stomach acid and ulcers. FDA officials said the amount of the impurity barely exceeds levels found in common foods. But the same chemical has been link...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs health onetime Source Type: news
(CNN) — The US Food and Drug Administration said on Friday that it has learned that some ranitidine — acid-reducing and heartburn medicines, including those known by the brand name Zantac — contain low levels of an impurity that could cause cancer. The nitrosamine impurity known as N-nitrosodimethylamine or NDMA has been classified as a probable human carcinogen based on lab tests, and this isn’t the first time that it has been detected in a common medication. Since last year, the FDA has been investigating NDMA and other impurities in blood pressure and heart failure medicines known as angiotensin ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN FDA Heartburn Source Type: news
Condition:   Advanced Metastatic Gastric Cancer Interventions:   Drug: Apatinib Mesylate;   Drug: Sintilimab Sponsor:   Fujian Cancer Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
ConclusionOur study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2  probably serves not only as a diagnostic biomarker, but also a new therapeutic target.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Our study demonstrated that high HOTAIR expression promote proliferation and metastasis in gastric cancer via miR ‐126/CXCR4 axis and downstream signaling pathways. AbstractHOTAIR, a well ‐known long noncoding RNAs (lncRNA), has been recognized to contribute to the tumor metastasis in several tumors. But its role in gastric cancer remains elusive. Here, we reported an increase in HOTAIR promoted proliferation and metastasis of gastric cancer cell lines. The HOTAIR and miR‐126 lev el was determined in 15 paired primary gastric cancer tissues and their adjacent noncancerous gastric tissues. Over‐expression or downreg...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
In conclusion, allosteric AKT inhibitors represent a promising class of drugs for chemoprevention and chemotherapy of cancers with E-cadherin loss.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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