Challenges to drug discovery for celiac disease and approaches to overcome them

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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Celiac disease (CD) is an immune mediated inflammatory enteropathy, triggered by gluten exposure in HLA-DQ2 and/or –DQ8 genetics. The presentation of celiac disease in children is changing, with increase in no...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Conditions:   Non-celiac Gluten Sensitivity;   Wheat Intolerance Intervention:   Other: bread Sponsor:   University of Hohenheim Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
There are few longitudinal data on whether childhood growth and pubertal timing may be impaired by adult-diagnosed celiac disease (CD). Through school health care records and national registers, we retrieved serial growth measurements on 37,672 Swedish boys born in 1945 to 1961, out of whom 72 (0.2%) were clinically diagnosed with CD as adults. Boys with, versus without, adult-diagnosed CD exhibited no appreciable mean differences in body mass index (BMI, kg/m2) and height (cm) at ages 8 or 20 to 21 years (childhood BMI, 15.9 [CD] vs 15.7 [comparators]; childhood height, 129.1 [CD] vs 128.6 [comparators]; adult BMI, 21.3 [...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communication: Gastroenterology: Celiac Disease Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Natural variants of α-gliadin peptides with wheat peptides with reduced toxicity in coeliac disease - CORRIGENDUM. Br J Nutr. 2020 May 22;:1 Authors: Japelj N, Suligoj T, Zhang W, Côrte-Real B, Messing J, Ciclitira PJ PMID: 32441231 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Abstract CONTEXT: An improvement of some autoimmune diseases associated with celiac disease (CD) has been observed after a gluten-free diet (GFD). OBJECTIVE: The aim of this longitudinal study was to evaluate the effect of a GFD on autoimmune pituitary impairment in patients with CD and potential/subclinical lymphocytic hypophysitis (LYH). DESIGN: Five-year longitudinal observational study. SETTING: Tertiary referral center for immunoendocrinology at the University of Campania "Luigi Vanvitelli". PATIENTS: Ninety-three newly diagnosed LYH patients (high titer of antipituitary antibodi...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Condition:   Educational Problems Intervention:   Other: Survey Sponsor:   Ege University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The rising prevalence of pediatric celiac disease(1, 2) and the variability in presentation(3) has prompted research and led to the evolution of published guidelines(4-8) regarding recognition and accurate diagnosis. The diagnosis is challenging because celiac disease causes an array of symptoms or no symptoms at all. Also, histopathological findings of duodenal biopsies consistent with celiac disease are seen in other common and uncommon pediatric intestinal diseases such as Crohn ’s disease, viral gastroenteritis, autoimmune enteropathy, and food protein-induced enteropathy(9-11).
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Editorials Source Type: research
Children and young adults with high blood levels of toxic chemicals found in pesticides, nonstick cookware and fire retardants were more likely to be diagnosed with celiac disease in a pilot study.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
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