Short-contact topical calcipotriene foam and fluorouracil 1% cream after cryotherapy for actinic keratosis

Background: Actinic keratoses (AKs) are precursor lesions to squamous cell carcinoma that arise from keratinocyte dysplasia. Treatment of AKs has traditionally involved cryotherapy, various topical agents such as topical 5-fluorouracil (5-FU), or combination therapy. Due to irritation with use of topical 5-FU, short-contact therapy 5-FU with cryotherapy has been reported. Vitamin D derivatives have also been reported as systemic anti-cancer agents, though clinical data for usage is limited mainly due to hypercalcemia as a dose-limiting adverse effect.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research