MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN.

CONCLUSION: Our findings demonstrate that miR-200b and miR-200c suppress the proliferation of KGN cells by targeting PTEN, and this might provide new evidence for abnormal proliferation of GCs in PCOS.
PMID: 31421682 [PubMed - in process]

Source: Reproductive Biology - August 16, 2019 Category: Reproduction Medicine Authors: He T, Sun Y, Zhang Y, Zhao S, Zheng Y, Hao G, Shi Y Tags: Reprod Biol Endocrinol Source Type: research