Brain imaging in epilepsy.

Brain imaging in epilepsy. Pract Neurol. 2019 Aug 16;: Authors: Duncan JS Abstract Brain imaging with MRI identifies structural cerebral pathology that may give rise to seizures. The greatest yield is from MRI at 3T using epilepsy protocols, and reported by expert neuroradiologists who possess the full clinical data. X-ray CT scanning has a role in assessing patients with seizures in the context of an acute neurological illness. Identifying a relevant structural lesion with MRI is fundamental in the consideration of epilepsy surgery; it is crucial to establish if a lesion is relevant to the epilepsy or not. If no lesion is identified, developmental MRI and image processing may identify a subtle abnormality. Positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) may identify focal functional abnormalities that infer the location of an epileptic focus. Functional MRI is useful for localising eloquent cortex, and tractography delineates crucial white matter tracts, so that these may be avoided in epilepsy surgery. Reviewing data in three dimensions aids visualisation of structural relationships and helps surgical planning. PMID: 31420416 [PubMed - as supplied by publisher]
Source: Practical Neurology - Category: Neurology Authors: Tags: Pract Neurol Source Type: research

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We examined the abundance of synaptic F-actin, analyzed the hippocampal F-actin/G-actin (F/G) ratio and pCofilin, and evaluated the number of hippocampal neurons and pre/postsynaptic markers in pilocarpine-induced status epilepticus mice with or without administration of dexamethasone (DEX). We found that the latency of Stage 3 seizures increased, the mortality decreased, the damage to the synaptic F-actin cytoskeleton in the hippocampal subfields was significantly attenuated, and a greater number of postsynaptic structures were retained in the hippocampal subfields after treatment with DEX. These results indicate that tre...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: Several clinical characteristics correlate with specific equipment needs. CLINICAL REHABILITATION IMPACT: The definition of the clinical characteristics with a potential predicting value, may facilitate the task of physician on choosing what is more appropriate to prescribe, as well as the authorizing office responsible for evaluating the appropriateness of prescriptions. Furthermore, it could be possible to foresee the care needs in terms of type and number of aids / orthoses and to guarantee every disabled child the possibility to take advantage of the same opportunities. PMID: 32406225 [PubMed - a...
Source: European Journal of Physical and Rehabilitation Medicine - Category: Rehabilitation Authors: Tags: Eur J Phys Rehabil Med Source Type: research
Publication date: July 2020Source: Epilepsy &Behavior, Volume 108Author(s): Chris L. Peterson, Honor Coleman, Christine Walker
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
CONCLUSION: Further person-centered research is needed in assessing the need for and usability of aids and equipment for the management of epilepsy. PMID: 32375096 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
by Ulrich Fabien Prodjinotho, Jakobo Lema, Matthew Lacorcia, Veronika Schmidt, Nermina Vejzagic, Chummy Sikasunge, Bernard Ngowi, Andrea Sylvia Winkler, Clarissa Prazeres da CostaTaenia solium cysticercosis and taeniasis (TSCT), caused by the tapewormT.solium, is a foodborne and zoonotic disease classified since 2010 by WHO as a neglected tropical isease. It causes considerable impact on health and economy and is one of the leading causes of acquired epilepsy in most endemic countries of Latin America, Sub-Saharan Africa, and Asia. There is some evidence that the prevalence of TSCT in high-income countries has recently inc...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In early April, about four months after a new, highly infectious coronavirus was first identified in China, an international group of scientists reported encouraging results from a study of an experimental drug for treating the viral disease known as COVID-19. It was a small study, reported in the New England Journal of Medicine, but showed that remdesivir, an unapproved drug that was originally developed to fight Ebola, helped 68% of patients with severe breathing problems due to COVID-19 to improve; 60% of those who relied on a ventilator to breathe and took the drug were able to wean themselves off the machines after 18...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Discussion Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future". Annu Rev Pharmacol Toxicol. 2020 Jan 06;60:1-6 Authors: Dolphin AC, Insel PA, Blaschke TF, Meyer UA Abstract "Ion Channels and Neuropharmacology: From the Past to the Future" is the main theme of articles in Volume 60 of the Annual Review of Pharmacology and Toxicology. Reviews in this volume discuss a wide spectrum of therapeutically relevant ion channels and GPCRs with a particular emphasis on structural studies that elucidate drug binding sites and mechanisms of action. The regulation of...
Source: Annual Review of Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Annu Rev Pharmacol Toxicol Source Type: research
Publication date: Available online 20 November 2019Source: Neuroscience LettersAuthor(s): Sathiya Sekar, Changiz TaghibiglouAbstractGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been well documented in glycolytic pathway. Independent of this, it has various other functions including stimulator of programmed cell death. Reports suggest that glutamate receptor AMPA type-2 subunit (GluA2) forms protein complex with GAPDH and internalized during excitotoxicity. Further, nuclear accumulation of GluA2 and GAPDH have been studied in neurological disorders like epilepsy and multiple sclerosis, and disruption of this complex...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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