Antimicrobial activity of Mycobacteriophage D29 Lysin B during < i > Mycobacterium ulcerans < /i > infection

In this study, we demonstrate for the first time that recombinant LysB displays lytic activity againstM.ulcerans isolates. Moreover, using a mouse model ofM.ulcerans footpad infection, we show that subcutaneous treatment with LysB prevented further bacterial proliferation, associated with IFN- γ and TNF production in the draining lymph node. These findings highlight the potential use of lysins as a novel therapeutic approach against this neglected tropical disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research