Remission in rheumatoid arthritis: missing objectives by using inadequate DAS28 targets
Nature Reviews Rheumatology, Published online: 19 August 2019; doi:10.1038/s41584-019-0279-6For too long, the definition of ‘remission’ in rheumatoid arthritis has been distorted by the widespread use of an inadequate tool, with consequences for clinical care and for making sense of clinical trial data. Has the time come to move away from DAS28-defined remission?
Publication date: Available online 17 September 2019Source: Reumatología Clínica (English Edition)Author(s): Carola Baliu-Piqué, Elena Nogués-Antich, Marta Cucurell-Palomas, Dolors Grados
Publication date: Available online 16 September 2019Source: Pharmacological ResearchAuthor(s): Fabiola Atzeni, Valeria Nucera, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini, Gianluca BonittaABSTRACTInterleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating ...
ConclusionTGP can not only improve symptoms, but also inhibit bone destruction. The therapeutic effect of TGP on CIA is mainly achieved by inhibiting spleen Tfh cell differentiation and GC formation through STAT3 signaling pathway.Graphical Abstract
Condition: Rheumatoid Arthritis Intervention: Diagnostic Test: CTHRC1 biomarker Sponsor: Assiut University Not yet recruiting
A 32-year-old male patient with rheumatoid arthritis affecting multiple joints without rheumatoid factor returns to the office for a follow-up visit with the nurse practitioner (NP). The patient states his overall pain has improved since his previous visit, although he rates the severity of his right shoulder and right wrist pain at a 5 on... [Read More]
MicroRNA‑34a‑3p inhibits proliferation of rheumatoid arthritis fibroblast‑like synoviocytes. Mol Med Rep. 2019 Jul 23;: Authors: Hou C, Wang D, Zhang L Abstract Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑3p in the pathogenesis of RA. FLS were collected from patients with RA and osteoarthritis (OA). The miR‑34a‑3p mi...
Researchers know human leukocyte antigen (HLA) molecules affect susceptibility to disease in general, and immunological disease in particular. In the case of ankylosing spondylitis (AS), the risk is primarily associated with HLA-B27, with smaller effects from other HLA alleles. Current thinking is that AS is caused by the presence of a genetically primed host because... [Read More]
CONCLUSION: Lack of adherence to T2T in the RA BIODAM cohort was evident in a substantial proportion despite being a protocol requirement and this could be predicted by clinical features. PMID: 31523049 [PubMed - as supplied by publisher]
Authors: Russell M, Yates M, Bechman K, Rutherford A, Subesinghe S, Lanyon P, Galloway J Abstract OBJECTIVE: To describe trends in acute hospital admissions due to gout in England, with rheumatoid arthritis (RA) as a comparator, alongside prescribing trends for common gout medications. METHODS: An ecological study was performed using NHS Digital Hospital Episode Statistics data to calculate the incidence of unplanned admissions with primary diagnoses of gout or RA in adults in England between April 2006 and March 2017. NHS Digital community prescription data for allopurinol, febuxostat and colchicine were consi...
Authors: Mavragani CP, Moutsopoulos HM Abstract We were delighted to read the letter by Killian, et al, which challenges the use of the terms primary and secondary human Sjögren syndrome (SS) even in experimental animal models of SS1 These terms were coined almost 40 years ago on the basis of a study that revealed clinical, immunologic, and genetic differences among patients expressing sicca manifestations alone and patients with rheumatoid arthritis (RA) and SS. PMID: 31523045 [PubMed - as supplied by publisher]