siRNA therapeutics for breast cancer: recent efforts in targeting metastasis, drug resistance, and immune evasion

Small interfering RNA (siRNA) has an established and precise mode of action to achieve protein knockdown. With the ability to target any protein, it is very attractive as a potential therapeutic for a plethora of diseases driven by the (over)expression of certain proteins. Utilizing siRNA to understand and treat cancer, a disease largely driven by genetic aberration, is thus actively investigated. However, the main hurdle for the clinical translation of siRNA therapeutics is to achieve effective delivery of siRNA molecules to tumors and the site of action, the cytosol, within cancer cells.
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research

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In this study, we used qualitative methods to better understand the changes in sexual life and related care strategies for breast cancer survivors. Twenty interviews were conducted on clinical patients enrolled in hospitals that received breast cancer treatment. The data were analysed by performing a constant comparative analysis. Three themes emerged: the causes of changes in sexual life, internal response strategies and external response strategies. Ten subthemes were identified. Changes in sexual life in patients with breast cancer in this study included changes related to body image, influence of friends and family, ag...
Source: International Journal of Qualitative Studies on Health and Well-being - Category: International Medicine & Public Health Tags: Int J Qual Stud Health Well-being Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Publication date: Available online 18 September 2019Source: Protein Expression and PurificationAuthor(s): Nazimuddin Khan, Jino Park, William L. Dean, Robert D. Gray, William Tse, Donghan Lee, T. Michael SaboAbstractThe protein ALL1 fused from chromosome 1q (AF1q) is overexpressed in a variety of cancers and acts to activate several signaling pathways that lead to oncogenesis. For example, AF1q has been shown to interact with T-cell Factor 7 (TCF7; also known as TCF1) from the Wnt/β-catenin pathway resulting in the transcriptional activation of the CD44 and the enhancement of breast cancer metastasis. Despite the impo...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Authors: Archer DF, Simon JA, Portman DJ, Goldstein SR, Goldstein I Abstract Introduction: Vulvovaginal atrophy (VVA), a component of the genitourinary syndrome of menopause, is a progressive condition due to decline in estrogen leading to vaginal and vulvar epithelial changes. Accompanying symptoms of dryness, irritation, burning, dysuria, and/or dyspareunia have a negative impact on quality of life. Ospemifene is a selective estrogen receptor modulator (SERM) approved by the FDA for moderate to severe dyspareunia and vaginal dryness due to postmenopausal VVA. Areas covered: PubMed was searched from inception to M...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Conclusions: Increased NK cells after NAC, together with increased CD4+ and CD8+ T-cells, and decreased CTLA-4+ T cells and VEGF correlate with beneficial therapeutic effects. Systemic activation of pNK cell activity and the presence of pre-NAC TILs may improve the elimination of Ax + together with decreased immunosuppression by VEGF in tumors.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 18 September 2019Source: Journal of the American College of RadiologyAuthor(s): Derek L. Nguyen, Emily B. Ambinder, Mary Kate Jones, Lisa A. Mullen, Susan C. HarveyAbstractPurposeEffective written communication directly affects health care outcomes. Since 2016, the complex language of state-mandated breast density notifications (BDNs) has been challenged, as it is perceived to be beyond the comprehension of most patients. The aim of this study was to assess whether a revised BDN written at a lower reading grade level improves understanding compared with the current state-mandated BDN.Meth...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Publication date: Available online 18 September 2019Source: Journal of the American College of RadiologyAuthor(s): Cindy S. Lee, Heidi Ashih, Debapriya Sengupta, Edward A. Sickles, Margarita Zuley, Etta PisanoAbstractObjectiveThere is insufficient large-scale evidence for screening mammography in women
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Condition:   Postoperative Pain Interventions:   Procedure: pectoral nerves block group;   Drug: Ketamine plus magnesium group;   Drug: Control group Sponsor:   National Cancer Institute, Egypt Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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