Short-Term Diabetes Remission Outcomes in Patients with BMI ≤ 30 kg/m 2 Following Sleeve Gastrectomy

AbstractBackgroundSleeve gastrectomy (SG) has become the most popular bariatric procedure. Although bariatric surgery is recommended for type 2 diabetes mellitus (T2DM) in Asian patients with BMI 27.5 –32.4 kg/m2, reported evidences, especially following SG, are still lacking.MethodsPatients ’ data from June 2016 to June 2018 that underwent SG as primary surgery at our setting were analyzed. Patients with T2DM, without insulin use and BMI 27.5–30 kg/m2, were our main criteria. Preoperative and postoperative parameters were as such: age, BMI, T2DM duration, anti-diabetic medications, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), insulin, C-peptide, and homeostatic model assessment-insulin resistance (HOMA-IR). Follow-up duration was at 1, 3, 6, and 12  months.ResultsEighteen patients (7 male and 11 female) were presented for this study. The mean age and diabetes duration were 46.3  ± 11.9 years and 31.8 ± 26.5 months, respectively. The mean preoperative vs postoperative 12-month assessment was as such: BMI 29.3 ± 0.9 vs 23.9 ± 0.9 kg/m2, FPG 8.4  ± 3.1 vs 5.6 ± 0.7 mmol/L, HbA1c 8.3 ± 1.8 vs 5.9 ± 0.7%, insulin 103.9 ± 47.4 vs 53.9 ± 13.1 pmol/L, C-peptide 1.90 ± 1.22 vs 1.08&...
Source: Obesity Surgery - Category: Surgery Source Type: research

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AbstractBariatric surgery (BS), including sleeve gastrectomy (SG), gastric bypass (GB), and ileal transposition (IT), is one of the approaches currently used for the correction of metabolic disturbances in type 2 diabetes mellitus (DM2) with obesity. However, the efficiency of these approaches and their impact on hypothalamic signaling and hormonal status in severe forms of DM2 without obesity remain poorly characterized. The aim of this work is to study the effect of IT, SG, and GB on insulin, leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) levels in the blood and on the expression of the genes encoding the main comp...
Source: Advances in Gerontology - Category: Geriatrics Source Type: research
AbstractIntroductionAvailable clinical data on the influence of baseline HbA1c postoperative morbidity and readmission after laparoscopic sleeve gastrectomy is scarce. This prompted us to conduct a multicenter retrospective study evaluating the influence of chronic hyperglycemia on postoperative course among patients undergoing laparoscopic sleeve gastrectomy (SG). We aimed to investigate the influence of baseline HbA1c levels on postoperative outcomes in patients after SG.Material and MethodsWe conducted a multicenter retrospective cohort study of consecutive patients who underwent SG from March 2017 to March 2018 in seve...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsBariatric surgery is a safe and effective treatment modality in patients who are human immunodeficiency virus positive with obesity and type 2 diabetes mellitus.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact,...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Wang FG, Bai RX, Yan WM, Yan M, Dong LY, Song MM Abstract The modulation of the gut microbiota was recently deemed one of the mechanisms responsible for the excellent outcomes of bariatric surgery. However, to date, only few studies have assessed this, and they have high heterogeneity. In the present study, next-generation 16S ribosomal DNA amplicon sequencing was used to characterize the gut microbiota of healthy volunteers, as well as patients prior to and after sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). Significant differences in α diversity, β diversity and species were iden...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ConclusionSynchronous VHR and BS in a bariatric unit is feasible with low recurrence rate. Laparoscopic VHR has lower complication rates than open, apart from seroma formation. Patients with diabetes have higher risk of infection.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionLSG has a significant effect on patients with type 2 diabetes mellitus whose BMI less than 30  kg/m2 in a short time, but its long-term effectiveness needs to be further followed up.
Source: Obesity Surgery - Category: Surgery Source Type: research
Obesity and its associated metabolic syndrome have become a major concern and burden for public health in the US and worldwide [1]. Although obesity by itself is detrimental to the overall health and life expectancy of a patient, the most important factors that concern patients and will affect their quality of life and longevity are the obesity-related comorbidities such as type 2 diabetes mellitus (T2DM) [2].The relationship between obesity and the development of T2DM is well known. Obesity is considered a major independent risk factor, having been well established several times in the literature with up to 90% of T2DM pa...
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
ConclusionCurrent network meta ‐analysis indicated that BPD or mini‐GBP achieved higher diabetes remission rates than the other procedures. However, the result needs to be interpreted with caution considering that these procedures were in the minority of bariatric surgeries.
Source: Obesity Reviews - Category: Eating Disorders & Weight Management Authors: Tags: Obesity Surgery/Obesity Comorbidity Source Type: research
Background: Longitudinal studies have shown that bariatric and metabolic surgery is associated with significant reduction in cardiovascular events and mortality. The Surgical Treatment And Medications Potentially Eradicate Diabetes Efficiently (STAMPEDE) trial showed that 5-years after randomization, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) were superior to intensive medical therapy (IMT) alone in achieving glycemic control in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess long-term changes in cardiovascular biomarkers after surgical versus medical treatment of T2DM.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
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