Atorvastatin Inhibited ROS Generation and Increased IL-1 β And IL-6 Release by Mononuclear Cells from Diabetic Patients.

CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

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(Natural News) Almost every major class of prescription drug raises your risk of developing Type-2 diabetes. Taking statins, antihypertensives, immunosuppressants, antipsychotics, antiretrovirals, and/or corticosteroids increases your risk of developing type 2 diabetes mellitus. Now researchers find that prostate drugs also play a role in the development of Type-2 diabetes. Their research was published in the...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), fibrosis, cirrhosis or Hepatocellular Cancer (HCC). Nevertheless, Cardiovascular Disease (CVD) is the most common cause of morbidity and mortality in NAFLD/NASH patients. Current guidelines suggest the use of p...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Background and Aims: The aim of study is to evaluate the effect of statin on endothelial dysfuncion (ED) and soluble endoglin as an indicator of vascular injury and ED in type 2 diabetes mellitus (DM2) and hypercholesterolemia (H).
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research
Background and Aims: To study the influence of middle-dose statin therapy on endothelial function in the combined course of arterial hypertension (AH), type 2 diabetes mellitus (DM2T) and subclinical hypothyroidism (SH).
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research
Background and Aims: Dyslipidemia is a strong predictor for cardiovascular diseases and its prevalence is rising rapidly worldwide. Saroglitazar (Lipaglyn ®; Zydus Cadila, Ahmedabad, India), a novel dual peroxisome proliferator activated receptor agonist, is approved in India for management of diabetic dyslipidemia and hypertriglyceridemia in type 2 diabetes mellitus not controlled by statin alone. To evaluate the effect of saroglitazar in dyslipidem ia, this 24-week clinical trial was conducted from December-2014 to October-2017 in India.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: E-poster session Source Type: research
Background and Aims: Dyslipidaemia is a known risk factor for cardiovascular diseases (CVDs). With the rising prevalence of dyslipidaemia, CVDs have emerged as major public health threats globally. Non high-density lipoprotein (non HDL)/HDL ratio and atherogenic index of plasma (AIP) are strong predictors of CVDs. Saroglitazar (Lipaglyn ®; Zydus Cadila, Ahmedabad, India) is a novel dual peroxisome proliferator activated receptor agonist and is approved in India for management of diabetic dyslipidaemia and hypertriglyceridemia in type 2 diabetes mellitus not controlled by statin alone.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: E-poster session Source Type: research
Background and Aims: Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk for cardiovascular disease, atherogenic dyslipidemia and postprandial hyperlipidemia. While statins have shown to improve diabetic dyslipidemia, the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on postprandial lipemia in T2DM have not been evaluated in detail.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: E-poster session Source Type: research
apoM is a minor HDL apolipoprotein and carrier for sphingosine-1-phosphate (S1P). HDL apoM and S1P concentrations are inversely associated with atherosclerosis progression in rodents. We evaluated associations between plasma concentrations of S1P, plasma concentrations of apoM, and HDL apoM levels with prevalent subclinical atherosclerosis and mortality in the African American-Diabetes Heart Study participants (N = 545). Associations between plasma S1P, plasma apoM, and HDL apoM with subclinical atherosclerosis and mortality were assessed using multivariate parametric, nonparametric, and Cox proportional hazards models. At...
Source: The Journal of Lipid Research - Category: Lipidology Authors: Tags: Patient-Oriented and Epidemiological Research Source Type: research
Conclusions: Compared with 1996, participants entering CR in 2015 were older, more overweight, and had a higher prevalence of coronary risk factors. Lipid values improved substantially concurrent with increased statin use. While the percentage of female participants increased, they continue to be underrepresented. Patients with heart valve repair/replacement now constitute 10.6% of the patients enrolled. Clinical programs need to recognize changing characteristics of attendees to best tailor interventions.
Source: Journal of Cardiopulmonary Rehabilitation - Category: Rehabilitation Tags: Cardiac Rehabilitation Source Type: research
 The World Health Organization's latestguideline on risk reduction of cognitive decline and dementia has been published. This guideline provides global, evidence-informed recommendations on how to reduce the risk of cognitive decline and dementia.It features evidence from reviews of theCochrane Dementia and Cognitive Improvement group in 3 of the guideline ’s  evidence profiles - Physical activity interventions, Management of diabetes and Management of dyslipidaemia. The featured reviews are:Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Effect of the...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
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