Non-homologous end joining is more important than proton linear energy transfer in dictating cell death

To identify biological factors that may yield a therapeutic advantage of proton therapy versus photon therapy. Specifically, the role of non-homologous end-joining (NHEJ) and homologous recombination (HR) in the survival of cells in response to clinical photon and proton beams.

Source: International Journal of Radiation Oncology * Biology * Physics - August 15, 2019 Category: Radiology Authors: Scott J. Bright, David B. Flint, Sharmistha Chakraborty, Conor H. McFadden, David S. Yoon, Lawrence Bronk, Uwe Titt, Radhe Mohan, David R. Grosshans, Pavel Sumazin, Simona F. Shaitelman, Aroumougame Asaithamby, Gabriel O. Sawakuchi Source Type: research