Elevated insulin levels following 7 days of increased sedentary time are due to lower hepatic extraction and not higher insulin secretion

Applied Physiology, Nutrition, and Metabolism, e-First Articles. Higher insulin following sedentary behavior may be due to increased insulin secretion (IS), decreased hepatic insulin extraction (HIE), or a combination of both. Ten healthy adults completed glucose tolerance tests following 7 days of normal activity and 7 days of increased sitting. There were no differences in IS; however, HIE at 120 min after ingestion (85.4% ± 7.2% vs. 74.6% ± 6.6%, p< 0.05) and the area under the curve (73.6% ± 9.4% vs. 67.5% ± 11.3%, p< 0.05) were reduced following 7 days of increased sedentary time.
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research