Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model.

CONCLUSION: The activation of the SphK1-S1P pathway may contribute to tubulointerstitial fibrosis in UUO kidneys by affecting fibrotic signaling within renal cells independent of immune modulation. PMID: 31416077 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31416077?dopt=Abstract

Source: American Journal of Nephrology - August 14, 2019 Category: Urology & Nephrology Authors: Zhang X, Wang W, Ji XY, Ritter JK, Li N Tags: Am J Nephrol Source Type: research

More News: Genetics | Study | Ureter and Renal Pelvis Cancer | Urology & Nephrology