Intralesional Triamcinolone Acetonide Therapy for Inflammatory Oral Ulcers

Publication date: Available online 13 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Paolo J. Fantozzi, Nathaniel Treister, Revathi Shekar, Sook-Bin Woo, Alessandro VillaAbstractObjectivesTo report on the clinical indications and treatment outcomes of intralesional steroid therapy (IST) for oral ulcerative conditions in an oral medicine practice.Study DesignA retrospective single-center study of patients with oral ulcerative conditions who were treated with IST. Demographic data, clinical diagnosis of the oral condition, size of the ulcer and pain were abstracted from electronic medical records.ResultsNinety-three patients (51 females [54.8%]) were treated for persistent traumatic oral ulcers (n=38; 40.8%), ulcers in oral chronic graft-versus-host disease (n=23; 24.7%), oral lichen planus (n=19; 20.4%), and other conditions (14.0%). Complete resolution was achieved in 81.7% of patients in a median of 96 days (range: 10-357), with 80% fully healed in a median of 84 days (range: 10-140). Overall patients received a median of two injections (range: 1-5) and a median dose of 12 mg per injection (range: 2-36). Nearly half of patients were also treated with concomitant topical steroid therapy. After the first injection, the median pain score reduced from five (range: 1-10) to one (range: 0-10; p
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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Background: Oral lichen planus (OLP) is a chronic disease without any definitive treatment. Localcorticosteroids are often prescribed, but their efficacy has been questioned by many studies. Thepurpose of this study was to investigate the effect of nano ‑based triamcinolone acetonide gel (NT)and compare it with conventional triamcinolone gel (CT) on OLP.Materials and Methods: In this triple ‑blind randomized clinical trial study, 40 patients with ErosiveOLP were divided into two groups receiving (CT) and (NT). The patients were requested to applythem four times a day for 2 weeks. The severity of pain was evaluated thro...
Source: Dental Research Journal - Category: Dentistry Source Type: research
CONCLUSIONS: TENS is beneficial in the field of dermatology, particularly involving the relief of chronic pruritus. PMID: 31418608 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
ConclusionSince CUS has overlapping clinical, histological, and immunofluorescence features with lichen planus and vesiculobullous diseases, clinicians and pathologists should consider this unusual, but significant, entity whenever oral ulcerative diseases with mixed features are encountered.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionThe application of HA is suggested, and is an effective substitute for TA in the treatment of OLP.
Source: Journal of Investigative and Clinical Dentistry - Category: Dentistry Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionGreater severity of OLP and OLL seems to be associated with increased levels of anxiety, higher scores of oral health impact profile, and decreased QoL.Clinical relevancePatients with severe OLP/OLL may benefit from additional therapeutic treatments, such as psychological and/or psychiatric management, concomitant to treatment specific to oral lesions.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
ConclusionThe application of HA is suggested, and is an effective substitute for TA in the treatment of OLP.
Source: Journal of Investigative and Clinical Dentistry - Category: Dentistry Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study assesses the demographic, clinical, histologic, and DIF features of CUS. It is important to differentiate CUS from LP and other vesiculobullous diseases (VBD) because lesions of CUS are resistant to steroid therapy, which is typically used to control LP and VBD. A literature review and IRB-approved retrospective search of CUS was performed within the archives of the University of Florida (UF) Oral Pathology Biopsy Service from 2007 to 2017. Fifty-two cases were identified from the literature and seventeen new cases were identified in our series. All UF patients were female and the median age was 64-years. The ma...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
Conclusion: Our study revealed numerous and varied intraoral manifestations among the patients with UC. The previous episodes of oral manifestations were also similar and reported exacerbation of oral manifestations during relapses. Thus, oral manifestations can be used as an indicator of relapse in UC.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
net P Abstract Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, which manifests as a succession of outbreaks. OLP was associated with salivary oxidative stress. Randomized, double blind, parallel-group study was performed. The sample consisted of 55 clinically and histopathologically diagnosed OLP patients. Twenty-six patients were treated with 2% Chamaemelum nobile gel and 29 with a placebo. Nonstimulated (basal) saliva was collected on the first day of the study and 4 weeks later. Salivary total antioxidant status (TAS) was evaluated by four different methods: two TAC (6-hydroxy-2,5,7,8-...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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