Characterization of Anti-Goat Podoplanin Monoclonal Antibody PMab-235 Using Immunohistochemistry Against Goat Tissues.
In this study, we investigated the epitopes of PMab-235 using enzyme-linked immunosorbent assay and immunohistochemistry. The results revealed that the critical epitope of PMab-235 produced by CBIS method is Arg75, Leu78, and Pro79 of gPDPN, which is included in PLD. The findings of our study can be applied to the production of more functional anti-gPDPN mAbs. PMID: 31403389 [PubMed - as supplied by publisher]
Condition: Peanut Allergy Interventions: Drug: INP20; Drug: Placebo Sponsors: InnoUp Farma S.L.; Syntax for Science, S.L Not yet recruiting
Condition: Non-Small Cell Lung Cancer Metastatic Interventions: Drug: Durvalumab; Drug: Pemetrexed; Drug: Carboplatin Sponsors: University of Utah; AstraZeneca Not yet recruiting
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Publication date: Available online 14 November 2019Source: Seminars in Cancer BiologyAuthor(s): Radhakrishnan Vishnubalaji, Shaath Hibah, Ramesh Elango, Nehad M. AlajezAbstractSubstantial evolution in cancer therapy has been witnessed lately, steering mainly towards immunotherapeutic approaches, replacing or in combination with classical therapies. Whereas the use of various immunotherapy approaches, such as adoptive T cell therapy, genetically-modified T cells, or immune checkpoint inhibitors, has been a triumph for cancer immunotherapy, the great challenge is the ability of the immune system to sustain long lasting anti-...
Publication date: Available online 14 November 2019Source: Nano TodayAuthor(s): Xiaochen Liu, Dangge Wang, Pengcheng Zhang, Yaping LiAbstractCheckpoint blockade immunotherapy revolutionizes the field of cancer therapy, among which anti-programmed cell death (anti-PD) therapy is the most successful one in clinic. Despite the tremendous advancement, anti-PD therapy is still limited by barriers such as low response rate and immune related adverse effects (AEs), which are mainly resulted from poor intratumoral infiltration of cytotoxic T lymphocytes and off-tumor distribution of the anti-PD drugs. To address these issues, nano...
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger researchers discovered a biological signature that could help identify which triple negative breast cancers might respond to immunotherapy and other treatments.
(University of California - San Francisco) In a breakthrough with important implications for the future of immunotherapy for breast cancer, UC San Francisco scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.
Antitumor immunity has emerged as a favorable byproduct of radiation therapy (RT), whereby tumor-associated antigens released from irradiated cells unleash innate and adaptive attacks on tumors located both within and outside the radiation field. RT-induced immune responses further provide actionable targets for overcoming tumor resistance to RT (R-RT); immunotherapy (IT) with checkpoint inhibitors or Toll-like receptor (TLR) agonists can markedly improve, if not synergize with, RT in preclinical models, and several of these drugs are currently investigated as radiosensitizers in patients. In an unbiased chemical-genetic s...
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. Despite multimodal treatment regimens, median survival in unselected patient cohorts is