The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis

This study shows that the levels of cAMP, progesterone, testosterone and expression of StAR decreased significantly in PFOA 50 and 100 µg/ml. PFOA affected cell populations significantly by decreasing the amount of diploid, proliferating, meiotic I and G2/M-phase cells in adult rat testis. However, PFOA did not affect fetal, proliferating or adult rat Sertoli cells but an increased tendency of apoptosis in fetal Leydig cells was observed.

Source: Reproductive Toxicology - August 13, 2019 Category: Toxicology Source Type: research