Protein kinase IKK{beta} activates IRF5 [Biochemistry]

The siRNA knockdown of IFN Regulatory Factor 5 (IRF5) in the human plasmacytoid dendritic cell line Gen2.2 prevented IFNβ production induced by compound CL097, a ligand for Toll-like receptor 7 (TLR7). CL097 also stimulated the phosphorylation of IRF5 at Ser462 and stimulated the nuclear translocation of wild-type IRF5, but not...

Source: Proceedings of the National Academy of Sciences - December 9, 2014 Category: Science Authors: Lopez-Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S., Cohen, P. Tags: Biological Sciences Source Type: research