Effect of FMD vaccination schedule of dams on the level and duration of maternally derived antibodies

Publication date: Available online 11 August 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): B. Sareyyüpoğlu, V. Gülyaz, C. Çokçalışkan, Y. Ünal, T. Çökülgen, E. Uzunlu, S. Gürcan, O. İlkAbstractVaccination against Foot and Mouth Disease (FMD) in pregnant cows is crucial to produce greater immunity in new born calves, especially in late gestation, as this directly affects neonatal immunity. Therefore, we aimed to investigate how late gestation FMD vaccination of pregnant cows affects the maternally derived antibodies in their offspring. Pregnant cows were vaccinated with and without booster vaccination during the 3rd months (early gestation vaccination, EGV) or the 6.5th months (late gestation vaccination, LGV). Their offspring were investigated for passive immunity transfer, maternal antibody duration, and the first vaccination age of calves (when the maternal antibody has waned sufficiently to allow the first vaccination). Antibody titers were analyzed by a virus neutralization test (VNT). A digital Brix refractometer (% Brix) was used to estimate passive antibody transfer efficiency measuring total protein (TP) content of calf blood sera and also colostrum IgG content. Two linear mixed effects models were fitted: one for the antibody titer values of the dams, and the other for the antibody titer values of calves before the vaccination. A marginal fixed effects model was also fitted to explore the effects of the dam titers on the antibody titers...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research